IndraLab

Statements

Metformin inhibits STAT1. 4 / 4
| 3 1
reach
"STAT1 inhibition of ADSCs by metformin significantly impairs induction of immunomodulatory markers, including indoleamine 2,3-dioxygenase, IL-10, and transforming growth factor-a, and inhibits T-cell proliferation in vitro [XREF_BIBR]."
33505595
eidos
"Metformin did not inhibit STAT1 or STAT3 phosphorylation ( Figures S1C and S1D ) ."
| PMC
eidos
"Metformin reduced STAT1 activation in CD4 + T cells and prevented binding of pSTAT1 to MX1 and ISG15 gene promoters ."
31160534
eidos
"In an obese mouse model , metformin effectively polarizes AT macrophages to an anti-inflammatory state via indirectly inhibiting SHP-1 expression , thereby downregulating NF-kappaB , STAT1 , CD80 , CD86 , TLR2 , TLR4 and inhibiting inflammation of AT ( 102 ) ."
34163481