IndraLab

Statements

AMPK activates KCNQ1. 3 / 3
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"KCNQ1 ubiqutination is promoted by AMPK activation via the ubiqutin protein ligase, Nedd4-2 in kidney cells."
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"Moreover, AICAR treatment of rat kidney slices ex vivo induced AMPK activation and intracellular redistribution of KCNQ1 from the basolateral membrane in collecting duct principal cells."
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"As a result, wild type and constitutively active AMPK significantly reduced KCNQ1 and KCNE1 mediated currents and reduced KCNQ1 abundance in the cell membrane."
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