IndraLab

Statements

KCNH2 inhibits LQT2. 2 / 2
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"LQT2 induced by hERG drug block (acquired LQT2) has received considerable attention over the past twenty years as hERG has been found to be uniquely susceptible to block by a wide array of drugs across multiple pharmaceutical classes XREF_BIBR, XREF_BIBR."
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"LQT1 and LQT2 are caused by loss-of-function mutations in KCNQ1 and KCNH2 genes, which encode cardiac slowly (I Ks) and rapidly (I Kr) activating delayed rectifier potassium channels, respectively."
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