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Dopamine inhibits IFNB1. 3 / 3
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"Immune subset studies indicated that DA suppressed secretion of IFN-beta, TNF-alpha, and IL-1beta by NK cells, as well as secretion of TNF-alpha by neutrophils and monocytes; however, DA upregulated IL-10 secretion by neutrophils, monocytes, B cells, Mphis, and DCs within the splenocyte population."
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"The link between Type-I IFNs and DA system integrity is supported by evidence that the lack of IFN-β signaling in murine models causes defective DA signaling, reduction of DA neurons, and movement disorders reminiscent of PD, which are associated with deficits in degradation pathways [61] ."
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"We show that both DA L and GDVII L disrupt IFN-beta gene transcription induction by IFN regulatory factor 3 (IRF-3) but do so at different points in the signaling pathway."
20610716