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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP7 activates methylation. 2 / 2

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"Felle et al. showed that USP7 stimulated both maintenance and de novo methylation activity of DNMT1 in vitro39 , and knockdown of USP7 reduced DNA methylation in three silenced genes , although whether USP7 knockdown affected global DNA methylation was not analyzed ."

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"In addition , it is formally possible that USP7 stimulates DNA methylation at a fraction of genomic regions , although overall it suppresses global DNA methylation ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...