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USP7 activates methylation. 2 / 2

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"Felle et al. showed that USP7 stimulated both maintenance and de novo methylation activity of DNMT1 in vitro39 , and knockdown of USP7 reduced DNA methylation in three silenced genes , although whether USP7 knockdown affected global DNA methylation was not analyzed ."

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"In addition , it is formally possible that USP7 stimulates DNA methylation at a fraction of genomic regions , although overall it suppresses global DNA methylation ."

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IndraLab

Statements

USP7 activates methylation. 2 / 2

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