IndraLab

Statements

CACNA1B binds RIMS1. 4 / 4
1 | 1 2
sparser
"This was found to cause an increase in somatic Cav2.2-mediated currents ( xref ), and also facilitates synaptic vesicle docking and release, possibly through enhanced Cav2.2 interactions with RIM1 and other SNAREs xref ( xref )."
32161339
hprd
No evidence text available
11438518
reach
"Subsequently, following deubiquitination, enhanced RIM1α directly binds to CaV2.2, resulting in increased CaV2.2 expression in the SPMs of the dorsal horn."
27629721
sparser
"RIM1 directly binds and tethers CaV2.2 channels to the synaptic cleft to facilitate neurotransmitter release [ xref ; xref ], this finding indicates that Cdk5-mediated phosphorylation of CaV2.2 may play a role in modulating CaV2.2 and RIM1 binding, thereby affecting neurotransmitter release ( xref , xref )."
32773603