IndraLab

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YOD1 activates Neoplasm Metastasis. 7 / 7
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"In addition, YOD1 deubiquitinase is highly expressed in PDAC and accelerates tumor metastasis, although the underlying mechanism remains unclear (Zhang et al., 2022)."
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"YOD1 knockdown MDA-MB-231 cells were injected into nude mice through the tail vein and the bioluminescent imaging showed YOD1 knockdown could significantly decrease the tumor burden and metastasis."
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"To investigate whether low YOD1 expression promotes ccRCC progression and metastasis via the ZNF24/VEGFA axis, we first cotransfected siYOD1 or Myc-ZNF24 plasmids into A498 and 786-O cells."
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"Conversely, increased YOD1 expression blocks ERK signaling by stabilizing TRIM33 activation, thereby inhibiting tumor invasion and lymph node metastasis in squamous cell carcinoma of the head and neck [25]."
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"YOD1 downregulation promoted ccRCC growth and metastasis both in vitro and in vivo."
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"Thus, DEX activates the miR-143-3p/epidermal growth factor receptor (EGFR) pathway substrate 8 axis, increases miR-493-5p, which targets RASL11B implicated in cancer development, decreases the expression of miR-1307, upregulates miR-185, which inactivates the Sry (sex determining region Y)-box 9 (SOX9)/Wnt/B-catenin pathway and miR-520a-3p that targets the metastases-inducing gene Yod1 coding for the deubiquitinating enzyme YOD1."
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"YOD1 promotes TNBC growth and metastasis in vivo."
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