IndraLab
Statements
reach
"(1) Constitutive binding partners, often as part of larger macromolecular complexes, e.g., USP22/SAGA-DUBm [167] and CSN5/COP9 signalosome [168] ; (2) low-affinity, transient binding partners, e.g., the USP19/SIAH complex [169] and USP8/NRDP1 [170] , or protein modifiers such as kinases, e.g., USP10/AMPKα [171] ; and (3) ubiquitinated substrates that bind DUBs by virtue of the Ub modification."