IndraLab

Statements

Sorafenib inhibits RELA. 5 / 6
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"Although p65 is the most frequently detected functional NF-κB subunit, we observed that c-Rel, but not p65, was dramatically inhibited by sorafenib in Mahlavu cells ( Fig. 4 B)."
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"(D, E) Western blot analysis indicates that sorafenib suppresses the nuclear transport of p65 caused by LPS."
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"Our results showed that sorafenib administration remarkably decreased the expression level of NF-κB (p65) in AA FLSs compared to the untreated AA FLSs."
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"(C) Western blot analysis indicates that sorafenib restricts the nuclear transport of p65."
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"Chromatin immunoprecipitation (ChIP) assays demonstrated that fluvastatin and sorafenib synergistically inhibited the binding of NF-kappaB p65 subunit to the SDF-1alpha promoter."
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