IndraLab

Statements

TNFAIP3 activates Neoplasm Metastasis. 3 / 3
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"Previously , our group showed that A20 promotes tumor metastasis through multi-monoubiquitylation of SNAIL1 in basal-like breast cancer ."
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reach
"However, when overexpressing TNFAIP3 and PLAU or upon activation of the NFkappaB pathway, all the inhibitory effects of SFE were reversed (XREF_FIG A-D), suggesting that SFE blocked the p65 promotion of TNFAIP3 and PLAU expression to inhibit ESCC cell proliferation and metastasis."
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"We found , through in vitro and in vivo experiments , that the A20 protein was more highly expressed in aggressive tumors and that A20 upregulation promoted metastasis ."
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