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TNFAIP3 activates Neoplasm Metastasis. 4 / 4
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"However, when overexpressing TNFAIP3 and PLAU or upon activation of the NFkappaB pathway, all the inhibitory effects of SFE were reversed (XREF_FIG A-D), suggesting that SFE blocked the p65 promotion of TNFAIP3 and PLAU expression to inhibit ESCC cell proliferation and metastasis."
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"Previously , our group showed that A20 promotes tumor metastasis through multi-monoubiquitylation of SNAIL1 in basal-like breast cancer ."
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"We found , through in vitro and in vivo experiments , that the A20 protein was more highly expressed in aggressive tumors and that A20 upregulation promoted metastasis ."
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"On the other hand, primary CRC cells secrete integrin β-like protein 1 (ITGBL1) in the form of extracellular vesicles (EVs), which stimulates TNFAIP3-mediated NF-κB signaling pathway, thereby activati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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