IndraLab

Statements

Tofacitinib inhibits RELA. 3 / 3
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"Furthermore, tofacitinib inhibited NFkappaBp65 in PsA explants and PsAFLS, a key transcriptional factor in the inflamed joint (XREF_FIG E)."
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"Mechanistically, we demonstrate that tofacitinib suppresses ox-LDL-mediated activation of NF-kappaB inhibitor alpha (IkappaB-alpha), accumulation of nuclear p65 and activation of nuclear factor kappaB (NF-kappaB) promoter, indicating that tofacitinib inhibits NF-kappaB activation."
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"XREF_BIBR In this study, tofacitinib inhibited pSTAT1, pSTAT3 and NFkappaBp65 in PsAFLS and PsA explants, an effect that was paralleled by induction of both SOCS3 and PIAS3."
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