IndraLab

Statements

USP10 activates CRC. 7 / 7
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"USP10 promotes CRC proliferation, oxaliplatin resistance, and DNA damage repair by stabilising XAB2."
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"Targeting USP10 by shRNA inhibited CRC proliferation and metastasis, and this effect was reversed by overexpression of NLRP7."
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"Together, these data suggest that USP10 is a tumor promoter in CRC."
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"Our in vitro and in vivo study reveals a new paradigm in CRC biology and unravels a novel mechanistic axis, demonstrating for the first time the involvement of inositol polyphosphate 4-phosphatase type II B (INPP4B) in USP10-mediated CRC modulation."
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"USP10 accelerates the CRC malignant process by upregulating NLRP7."
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"Overall, these findings suggest that USP10 promotes cell proliferation, oxaliplatin resistance, and DNA damage repair in CRC by stabilising XAB2."
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"In contrast, one study showed that USP10 enhanced CRC cell proliferation by stabilizing MSI2, an oncogenic factor.Vismodegib, a drug used for treating basal cell carcinoma, has been shown to decrease the activity of two DUBs, USP25 and USP28, as well as the levels of their substrates, such as c-MYC, in CRC cells[30]."
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