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USP13 inhibits phosphatidylinositol 3-kinase/protein kinase B signal transduction. 3 / 3
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"For example, overexpression of USP13 blocks the AKT signaling pathway and suppresses tumor cell proliferation, invasion, and glycolysis by upregulating PTEN, while USP13 levels are downregulated in breast, bladder, and oral squamous tumors, in correlation with PTEN levels (Fig. 3)."
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"It is assumed that overexpression of USP13 can block AKT signaling pathway, suppressing tumor cell proliferation, invasion, and glycolysis through up-regulating PTEN protein levels (Zhang et al., 2013; Xiang et al., 2015; Zhang et al., 2018; Man et al., 2019)."
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"For instance, in non-small-cell lung cancer (NSCLC), downregulation of USP13 inhibits MAPK/AKT signaling (Han et al., 2016)."
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