IndraLab

Statements

EGFR binds EGF and TGF. 4 / 4
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"Binding of EGF and TGF- to EGFR initiates a signal transduction process that results in the stimulation of cellular proliferation ."
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"Nimotuzumab is a recombinant humanized IgG1 monoclonal antibody directed against EGFR. xref Nimotuzumab binds to EGFR, thereby blocking the binding of EGF and TGF‐α to EGFR, and eventually inhibiting the EGFR signaling pathway."
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"Amphiregulin is one of the family of ligands, also including EGF and TGF-, that binds to the EGF receptor ."
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"These seven modules were enriched for diverse functions, such as chromatin organization, gene expression and signaling pathways, including EGF-EGFR, PI3K/AKT and TGF (Additional file xref : Table S3)."
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