IndraLab

Statements

USP10 activates mutated TP53. 4 / 4
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"Paradoxically, USP10 could promote cancer cell proliferation in mutant p53 background."
20096447
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"USP10 also displays activity toward mutant p53 and promotes the oncogenic effects of mutant p53 in tumor cells [12] ."
28587923
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"Notably, as USP10 can positively regulate both wild-type and mutant TP53, therefore, miR-138 could also play a dual role as an either tumor suppressor or an onco-miR in different cell context."
31695837
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"Furthermore, expression of USP10 increased mutant p53 stability (XREF_SUPPLEMENTARY), while downregulation of USP10 decreased mutant p53 stability (XREF_SUPPLEMENTARY), suggesting that USP10 regulates mutant p53 stability."
20096447