IndraLab

Statements

Silibinin inhibits NLRP3. 10 / 10
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"Silibinin treatment inhibited the activation of the NLRP3 inflammasome and suppressed DCA-induced pyroptosis."
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"Silybin has been shown to inhibit endoplasmic reticulum stress and the activation of the NLRP3 inflammasome in mice with fatty liver disease associated with metabolic dysfunction fed a high-fat diet [106]."
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"Zhang et al. showed that silybin significantly inhibits the assembly of NLRP3 inflammasome in mice with NAFLD 84."
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"In our study, we found that silybin inhibited endoplasmic reticulum stress and NLRP3 inflammasome activation in the livers of HFD fed mice and in cultured hepatocytes."
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"Of significance, treatment of monocytes with SB (silibinin) downregulates NF-κB pathway and inactivates NLRP1/NLRP3 inflammasomes in pregnant women with PE (preeclampsia), suggesting a prospective therapeutical strategy for APS-related APOs via abrogating inflammation (67)."
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"In addition, silybin inhibited the approach of calreticulin and translocase of outer membrane 20 (Tom20), prevented assembly of the NLRP3 inflammasome complex, and suppressed the accumulation of acetylated alpha-tubulin in the perinuclear region."
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"Silymarin prevents NLRP3 inflammasome activation and protects against intracerebral hemorrhage."
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"Silybin inhibits the activation of the NLRP3 inflammasome in THP-1 cells by reducing the production of intracellular ROS."
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"There is a higher endogenous activation of NLRP1/NLRP3 inflammasomes in the monocytes from preeclamptic women than normotensive pregnant women, but Silibinin can inhibit NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia [53]."
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"Studies reported administration of silibinin (a flavonoid complex) could reduce NLRP3 activation upon MUS stimulated monocytes."
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