IndraLab

Statements

BAP1 binds ASXL1/2. 5 / 5
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"The KMT2C/D-COMPASS-like complex is recruited to enhancers by the BAP1-ASXL1/2 complex, which facilitates enhancer priming (17,18)."
36108220
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"The tumor suppressor BAP1 associates with ASXL1/2 to form the core Polycomb complex PR and DUB, which catalyzes the removal of mono-ubiquitin from several substrates including histone H2A."
29069806
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"Cancer-associated BAP1 mutations lead loss of DUB activity and impair function of the BAP1-ASXL1/2 complex, causing an elevation in H2A ubiquitination levels, and subsequent cell cycle progression dysregulation (3)."
33446574
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"The core BAP1 and ASXL1/2 complex interacts with host cell factor-1 (HCF-1) and histone modifying complexes during cell division."
23714463
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"This work provides a structural basis upon which to interpret previous studies showing that the ASXL1/2 Deubad domains bind tightly to BAP1, and activate the complex by forming a composite binding site for ubiquitin xref , xref ."
30258054