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OTUD4 inhibits apoptotic process. 7 / 7
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"We further confirmed that increased OTUD4 prevented apoptosis in the lung tissue of CSE mouse model through TUNEL assay (Fig. 3E)."
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"In addition, we proved that knockdown of OTUD4 enhanced cell apoptosis in BEAS-2b through the TUNEL assay (Fig. 5D)."
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"Above results further demonstrated that OTUD4 silence promoted lung epithelial cell apoptosis.To verify whether OTUD4 could prevent the epithelia apoptosis, we overexpressed OTUD4 in BEAS-2b cells exposed to CSE."
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"Furthermore, TUNEL detection also confirmed that overexpression of OTUD4 can significantly reduce CSE induced lung cell apoptosis, while the apoptotic cells were significantly increased with tiplaxtinin treatment (Fig. 9G, H)."
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"In summary, the remarkable results of this study propose that overexpression of OTUD4 reduce cell apoptosis to protect against CSE treated lung epithelial cells and CSE mediated emphysematous model, which through PAI-1 activation."
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"Ovarian tumor family deubiquitinase 4 (OTUD4), a member of the OTU deubiquitinating enzyme, is implicated to decrease in cancer to regulate cell apoptosis."
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"Above all, this study added preliminary evidence that CSE induced OTUD4 reduction promoted epithelia apoptosis in COPD pathogenesis."
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