IndraLab

Statements

USP1 activates PARP1. 7 / 7
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"In line with the above experiments, we also observed that USP1 inhibition prevented PARP1 auto-PARylation and that it was regulated by the overexpression of USP1 but not of the catalytic inactive form USP1 (Fig. 5E and fig."
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"Secondly, we discover that GCN5 acetylates USP1 to enhance the affinity between USP1 and PARP1, thereby further stabilizing PARP1."
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"USP1 prevents PARP1 protein degradation."
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"Next, we found that the proteasome inhibitor MG132 reversed the decrease in PARP1 protein levels caused by USP1 knockdown, but not the increase in PARP1 protein caused by USP1 overexpression (Fig. 2B–D, Sup."
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"Only overexpression of wild-type USP1 prevented PARP1 protein degradation (Fig. 2J–K)."
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"USP1 prevents PARP1 degradation through deubiquitination."
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"USP1 enhances the proliferation, invasion, and metastasis of CCA by stabilizing PARP1."
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