IndraLab

Statements

USP18 activates Cell Survival. 6 / 6
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"Consistent with these findings, Colony forming assays also showed that USP18 knockdown decreased the cell viability of BxPC-3 cells, whereas overexpression of USP18 increased the cell viability of SW1990 cells (XREF_FIG and XREF_FIG)."
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"The results showed that knockdown of USP18 reduced cell viability and ovarian cancer proliferation ."
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"We next showed that siRNA depletion of USP18 in H1650 cells reduces cell viability in accordance with the screening data (Figure 1D)."
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"We showed here that USP18 knockdown reduced cell viability by destabilizing SLC7A11 to induce ferroptosis, which is blocked by either ectopic expression of SLC7A11 or treatment with a ferroptosis inhibitor."
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"The results showed that knockdown of USP18 reduced cell viability and ovarian cancer proliferation."
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"Beyond that, elevated USP18 could promote colorectal cancer cell survival after treatment with DDP [31]."
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