IndraLab

Statements

Pimozide inhibits KCNH2. 15 / 15
5 3 | 7
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"Haloperidol, pimozide, and fluspirilene inhibited HERG current with IC (50) of 1.36, 1.74, and 2.34 microM, and maximal block of 73%, 76% and 65%, respectively."
11377395
tas
No evidence text available
12747773
tas
No evidence text available
19534531
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"The IC 50 value for pimozide block of peak HERG tail currents measured 18.1 nM (13.7-23.9 nM, 95% C.L., Fig. 1B)."
10762666
tas
No evidence text available
15911273
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"Pimozide and sertindole, for example, have previously been shown to block HERG in the low nanomolar range (Rampe et al., 1998; Kang et al., 2000)."
12176106
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No evidence text available
15324906
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"These results suggest that pimozide inhibits HERG with high affinity and is selective for this channel relative to other human cardiac K + channels.Pimozide has been shown to prolong the QT interval a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10762666
reach
"However, with up to 5 muM testosterone and up to 12 hr of incubation, enough oocytes with acceptable membrane properties (input resistance of no less than 2 x 10 5 Omega at -80 mV) were available.Appl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11377395
ctd
No evidence text available
24052561
ctd
No evidence text available
15671647
ctd
No evidence text available
14678746
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"Pimozide also inhibits hERG (human Ether-a-go-go-related) K + -Channel (Kongsamut et al., 2002)."
29958636
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No evidence text available
21185626
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"Using patch clamp electrophysiology, we found that pimozide was a potent inhibitor of HERG displaying an IC (50) value of 18 nM."
10762666