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CYLD activates cell death. 36 / 39
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"Dox-induced expression of CYLD did not cause cell death, and the administration of TNF (at a concentration that alone would not kill HeLa cells) induced cell death (Fig. 3, I and J), indicating that overexpression of CYLD sensitizes cells to TNF-induced cell death."
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"The cell death is suppressed by knockdown of CYLD or RIP1 or RIP3 or MLKL, suggesting that this necrosis is necroptosis and mediated by CYLD-RIP1-RIP3-MLKL signaling pathway."
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"All of the results demonstrated that overexpression of CYLD promoted cell death and CYLD played an antitumor activity in the human lung cancer cells."
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"39 Thus, repression of CYLD may prevent cell death at the level of both TAK1 and RIP1."
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"After 8 days of treatment with all-trans-retinoic acid (ATRA) on the NB SK-N-BE 2) C cell line, the SUMOization of CYLD decreased, while its expression increased, which blocked the NF-κB signal transduction pathway and promoted cell death (Kobayashi et al., 2015)."
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"Firstly, we asked whether overexpression of CYLD-flag could induce cell apoptosis, which probably contributed to CYLD induced cell death."
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"CYLD knockdown also significantly inhibited TNF/IFNγ-induced cell death (Fig. 3, E and F), and combined knockdown of caspase-8 and CYLD inhibited TNF/IFNγ-induced cell death in an additive manner (Fig. 3, G and H)."
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"CYLD Limits Gene Activation and Enhances Cell Death in Response to TNF."
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"We have detected that overexpression of CYLD contributed to cell death of the lung cancer cells."
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"CYLD can limit TNF-induced prosurvival signaling and promote cell death [ 76-78 ] ."
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"Because not the basal but BafA1-induced cell death in MEF was inhibited by knockdown of CYLD (Fig. 6E), it is likely that CYLD mediates cell death in stressed cardiomyocytes via suppressing autophagy at the stage of autolysosome efflux."
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"Taken together, these results indicate that CYLD can promote autophagy inhibition-induced cell death most likely via suppressing autolysosome efflux in cardiomyocytes."
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"Cell death initiated by TNF in Cyld -/- MEFs expressing CYLD-D215A was blocked by the RIPK1 inhibitor Necrostatin-1 17 (XREF_FIG, compare panel 6 and panel 7), or by specific knockdown of Ripk1 or Ripk3 (XREF_FIG), demonstrating that RIPK1 and RIPK3 are downstream of CYLD."
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"Collectively, our results indicated that IFNγ-stimulated caspase-8 and CYLD upregulation additively promoted TNF/IFNγ-induced cell death in cancer cells."
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"A genome-wide siRNA screen linked CYLD to receptor interacting protein-1 (RIP1) kinase-mediated necroptosis; however, the exact mechanisms of CYLD-mediated cell death remain unknown."
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"These findings unravel the mechanisms of CYLD-mediated cell death signaling in damaged neurons in vitro and suggest a cell death-mediating role of CYLD in vivo."
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"We showed that CYLD dependent RIPK1 and RIPK3 necrosome formation occurred in neuronal cells exposed to ferroptosis activators and knockdown of the necroptosis-mediators CYLD, RIPK1 or RIPK3 attenuated cell death."
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"The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed a significant degree of protection exerted by both CYLD siRNA sequences in comparison to their respective controls (Fig. 1d; Supplementary Fig. S1b), and fluorescence-activated cell sorter (FACS) analysis of AnnexinV/propidium iodide (PI)-stained cells confirmed that CYLD depletion prevented oxidative cell death (Fig. 1e)."
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"In STAT1 KO HeLa cells, dox-induced expression of IRF1 also induced expression of CYLD and caspase-8 and caused cell death in the presence of TNF (Fig. 6 B), indicating that IRF1 is sufficient for the IFNγ-induced expression of CYLD and caspase-8.Next, we performed IRF1 chromatin immunoprecipitation (ChIP) followed by quantitative PCR (qPCR) and found that IRF1, but not the IRF1 W11R mutant variant, bound to the promoter regions of the CYLD and CASP8 loci (Fig. 6, C and D)."
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"The role of CYLD in promoting cell death is evident in mice as well as cell culture."
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"CYLD can limit TNF induced prosurvival signaling and promote cell death [XREF_BIBR - XREF_BIBR]."
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"Accordingly, CYLD mediates cell death and secondary brain damage in vitro and in vivo and may therefore represent a potential novel target for the treatment of brain injury."
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"In agreement with this observation, loss of A20 enhanced TNF driven cell death, which could be rescued by co-depletion of CYLD [ 59 ]."
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"This indicates that the protective effects of CYLD on photoreceptor cells are mediated by NF-κB activation.In conclusion, by establishing an experimental RD model, the expression of CYLD peaked on the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Increasing CYLD promotes apoptosis and increasing PNUTL enhances cell death via TGF."
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"IKK blockade reactivated CYLD, as evidenced by the reduction in RIPK1 ubiquitination, which led to the association of RIPK1 with the DISC, triggering cell death."
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"To understand the mechanism by which CYLD inactivation leads to cell death, we first analyzed the activation of Jun N-terminal kinase (JNK), which is known to trigger apoptosis in several cell types w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"21 Previously, it was reported that CYLD promotes induction of cell death by TNF-alpha."
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"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR In cell death assays, overexpression of CYLD significantly enhanced induction of cell death stimulated by TNF-alpha, but this effect was abolished in CLIPR-59 knock-down cells (XREF_FIG)."
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"However, more importantly, five recently published reports have highlighted that SPATA2 is crucial for recruiting CYLD to the TNFR1 signaling complex thus promoting its activation leading to TNF-induced cell death."
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"The results showed that CYLD knockdown in DU145 cells decreased cell death and intracellular lipid peroxidation levels (Fig. 3H, I), while CYLD overexpression in PC-3 and DU145 cells increased cell death and intracellular lipid peroxidation levels (Fig. 3J, K and supplemental Fig. 3D, E)."
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"Consistently, YAP knockdown could significantly decrease cell death and lipid peroxidation levels induced by CYLD overexpression in PC-3 cells (Fig. 6F–H)."
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"Otherwise overexpression of CYLD induced TNF-alpha-induced cell death in A549 cells and H460 cells."
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"Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death."
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"The tumor suppressor cylindromatosis (CYLD), which promotes RIPK1-dependent cell death, is also controlled by inhibitory phosphorylation by the IKK and TBK1 kinases [45]."
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"In control non targeting siRNA transfected cells, the treatment with TNFalpha induced at least 60-70% cell death, which is blocked by knockdown of cyld and tnfr1 but not by that of rip1 (XREF_FIG)."
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