IndraLab

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USP38 decreases the amount of TBK1. 3 / 3
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"Conversely, USP38 knockdown in THP-1 cells increased endogenous TBK1 protein levels in cells infected with VSV-EGFP or transfected with IC poly(I:C), but not in uninfected cells ( Figures 4 I and S3 E[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To understand the molecular mechanisms of USP38 action, we show that USP38 specifically interacts with active TBK1 after viral infection and inhibits type I IFN signaling at the level of TBK1."
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"As shown in Figure 8A and 8B, USP38 deficiency significantly decreased p-TBK1 level after AB surgery, whereas USP38 overexpression dramatically increased the level of p-TBK1."
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