IndraLab

Statements

VEGFA binds NRP1 and NRP2. 9 / 9
| 9
sparser
"15 It is notable that VEGF-A binds to both NRP-1 and NRP-2 but has higher affinity for NRP-1 due to amino acid substitutions within the first loop region of NRP-1 that provide additional contacts between NRP-1 Thr299 and VEGF-A Glu154 (Figure 1B,C)."
33787218
sparser
"Hence, though VEGF-A interacts with both NRP-1 and NRP-2, it exhibits a fifty-fold greater affinity for NRP-1."
33815686
sparser
"Among many downstream factors of VEGFA [ xref , xref ], we found it was VEGFR2 rather than NRP1 and NRP2 associated with VEGFA in our study."
28042950
sparser
"It is notable that VEGF-A binds to both NRP-1 and NRP-2, but has higher affinity for NRP-1 due to amino acid substitutions within the first loop region of NRP-1 that provide additional contacts between NRP-1 Thr299 and VEGF-A Glu154 ( xref , xref ) xref ."
32995772
sparser
"Hence, though VEGF-A interacts with both NRP-1 and NRP-2, it exhibits a fifty-fold greater affinity for NRP-1."
| DOI
sparser
"Considering that the interaction of S1 CendR peptide with NRP-1 mimics that of its endogenous partner VEGF-A 164, the possible basis of differential binding of VEGF-A to NRP-1 and NRP-2 could be relevant to that of S1 to the two NRP isoforms."
| DOI
sparser
"VEGF-A 165 binding to NRP1 and NRP2 is important for migration of endothelial cells."
21653826
sparser
"Considering that the interaction of S1 CendR peptide with NRP-1 mimics that of its endogenous partner VEGF-A 164, the possible basis of differential binding of VEGF-A to NRP-1 and NRP-2 could be relevant to that of S1 to the two NRP isoforms."
33815686
sparser
"However, this interaction alone is insufficient to explain the marked difference in potency of VEGF-A binding to Nrp1 and Nrp2, therefore other molecular determinants of this preferential binding must exist."
23145112