IndraLab

Statements

OTUB1 activates Cell Survival. 7 / 7
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"A growing body of literature demonstrates that the DUB Otubain 1 (OTUB1) regulates many cancer associated signaling pathways including MAPK, ERa, epithelial-mesenchymal transition (EMT), RHOa, mTORC1, FOXM1 and P53 to promote tumor cell survival, proliferation, invasiveness and therapeutic resistance."
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"Knockdown of OTUB1 inhibited cell viability and proliferation , as well as migration and invasion of RCC cells ."
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"Data from CCK8 ( Fig. 2b ) and colony formation assay ( Fig. 2c ) indicated that knockdown of OTUB1 decreased cell viability and inhibited cell proliferation of RCC cells ."
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"OTUB1 depletion in melanoma cells decreased cell viability and caused simultaneous accumulation of cells in the sub-G1 phase, indicating an increase in the apoptotic-cell population."
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"As shown in Fig. 4 b, OTUB1 overexpression significantly elevated the cell viability at 48 h, whereas silencing OTUB1 suppressed the cell ability under the plasmid transfection of OTUB1-shRAN1 or OTUB[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Otub1 promotes MM cell survival and MM tumor growth."
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"In supplementary materials Fig. S1b, we found that OTUB1 knockdown in SCC-25 cells also inhibited cell viability."
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