IndraLab

Statements

UCHL1 activates SNCA. 5 / 5
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"The UCH-L1 ligase activity could produce an elevation of the cytoplasmic concentration of alpha-synuclein by inhibiting its " normal " degradation."
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"Fractions containing both UCH-L1 and alpha-synuclein were treated with a UCH-L1 antibody (Chemicon, rabbit polyclonal), an alpha-synuclein antibody (Transduction Lab), or buffer (as a control), and th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"UCH-L1, especially those variants linked to higher susceptibility to PD, causes the accumulation of alpha-synuclein in cultured cells, an effect that can not be explained by its recognized hydrolase activity."
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"This result indicates that UCH-L1 transfection does not increase alpha-synuclein expression and that accumulation of alpha-synuclein resulted from inhibition of its degradation."
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"This further sustains the notion that UCH-L1 plays a pathological role in inclusion formation, e.g., in PD, and may modulate the turnover of alpha-syn."
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