IndraLab

Statements

CACNA1A inhibits serotonin. 2 / 2
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"The evolutionary and functional relationship between the UNC-2 channel and the migraine associated CACNA1A channel was further confirmed through experiments showing that transgenic expression of human CACNA1A can suppress the lethargic and serotonin deficient phenotypes of unc-2 mutant animals."
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"Three drugs have been approved by the FDA for the treatment of pain in FM: pregabalin, which binds to a voltage-dependent, presynaptic calcium channel, and duloxetine and milnacipran, which selectively inhibit reuptake of serotonin and norepinephrine, respectively."
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