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KCNMA1 activates metabolic process. 4 / 4
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"However, the observations noted in this study indicate that this may not be true for the SLO mediated metabolism of DMA."
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"NS-1619 also reduces epileptiform like synaptic activity triggered in hippocampal slices by removal of Mg2+, thus providing an alternative therapeutic approach to intractable forms of epilepsy.Furthermore, the selective BK channel opener BMS204352 has been successfully employed to partially rescue abnormal dendritic spines morphology, behavioural and cognitive defects as well as alterations in glutamate neurotransmission and metabolism in Fmr1knock-out mice (He ` bert et al. 2014)."
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"Importantly, intact SLO function is necessary for changes manifested in the slob null phenotype, implying that the modulation of SLO by SLOB mediates the alterations in gene expression and metabolism."
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"In db/db mice, the BK channel dependent pathway was destroyed, resulting in the abnormal coupling of the TRPV1 channel mediated coronary blood flow and cardiac metabolism."
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