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JOSD1 activates cell death. 2 / 2
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"We found that overexpression of SOCS1 caused a decrease in CC3 expression and number of dead cells (Supplementary Fig 3A–C), while its downregulation conversely caused an increase in CC3 expression (Fig. 5A) and number of dead cells (Fig. 5B) under proteasomal inhibition in a manner similar to JOSD1.Next, we sought to determine whether SOCS1 sufficiency was a prerequisite for JOSD1’s ability to modulate cell death under proteotoxic conditions."
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"Consistently, adenovirus-mediated overexpression of JOSD1 in primary mouse hepatocytes caused a marked decline in cell death under proteotoxicity (Fig. 2C)."
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