IndraLab

Statements

USP4 binds RIGI. 5 / 8
2 | 1 4
sparser
"Several USPs can modulate both K63 and K48-linked polyubiquitination while USP4 can interact with RIG-I and target its K48-linked polyubiquitination and stabilize its expression to upregulate IFN-β expression then modify antiviral innate immune responses [ xref – xref ]."
32669974
reach
"Furthermore, whereas our results showed that USP15 efficiently interacted with TRIM25 specifically in infected cells, USP4 constitutively interacts with RIG-I."
24399297
sparser
"USP4 can directly target RIG-I and interact with RIG-I ( Wang et al., 2013 )."
32407768
sparser
"USP4 interacts with RIG-I to remove the K48-linked polyubiquitination conjugate from RIG-I, thereby maintaining RIG-I stability and then acting antiviral functions [ 15 ]."
35227882
sparser
"USP4 interacts with RIG-I and removes K48-linked polyubiquitination chains resulting in the stabilization of RIG-I ( Wang et al., 2013 )."
33713958