IndraLab

Statements

TEA inhibits KCNH2. 9 / 9
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"Both TEA and 4-AP are non selective K + channel blockers capable of inhibiting Eag and HERG as well as other voltage gated K + channels."
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"Both K + channel blockers, 4-AP and TEA, significantly inhibited the proliferation of Eag and HERG positive SK-OV-3 cells, confirming data by Zhanping et al., on the A2780 ovarian cancer line [XREF_BIBR]."
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"The ratio of the inactivation rate in the absence of QA (k inact -QA) to the inactivation rate in the presence of QA at its K i value (k inact + QA) is presented in Fig. 4 B. Small QAs such as TMA slo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, TEA containing external solutions are known to inhibit hERG channel inactivation (50), making that possibility less likely in our experiments."
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"EAG channels have been described as channels with low sensitivity to classical channel blockers like tetraethylammonium (TEA) or 4-amino-pyridine or the HERG blocker E4031 [15,21]."
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"Like other voltage gated K + channels, HERG channels are blocked by internal TEA (Smith et al. 1996)."
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"On average, 30 mM TEA inhibited the tail currents of hERG channels by 36% +/- 4% (n = 14; Fig. 1 A)."
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"Because external TEA + slows fast closing of HERG channels at positive potentials, this closing has been considered analogous to C-type inactivation."
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"Application of external TEA slows the kinetics of HERG inactivation, as though channels can not inactivate when TEA is bound."
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