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USP22 increases the amount of FASN. 3 / 3
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"Moreover, the depletion of USP22 decreased the levels of FASN and Ki-67 in mouse xenograft tumors, and exogenous FASN rescued those effects (Fig. 6H)."
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"We, therefore, screened a panel of DUBs by transfecting the cDNA plasmids of 36 DUBs into 293T cells, and found USP2, USP14, USP22, and USP30 upregulated FASN levels (Fig. S2A)."
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"As we expected, depletion of USP22 decreased the levels of FASN in CRC cells (Fig. 3A)."
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