IndraLab

Statements


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"As TNFAIP3 inhibits NF-kappaB activation and IEC death, expression of TNFAIP3 in IEC may provide an avenue to inhibit IEC NF-kappaB activation without inducing IEC death and inflammation."

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"These results indicate that TNFAIP3 expression in IEC prevents colitis involving DSS induced IEC death, but not colitis driven by T cell mediated inflammation."

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"Intestinal epithelial cell (IEC) expression of TNFAIP3 improves barrier function and tight junction integrity and prevents dextran sulfate sodium (DSS)-induced IEC death and colitis."