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Nickel(2+) inhibits IRF3. 2 / 2

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"The present study demonstrated that nickel decreased interferon regulatory proteins IRF3 and IRF7, and activated NF- kappaB, resulting in DeltaNp63 suppression and then p21 up-regulation."

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"In summary, our results showed that in keratinocytes nickel is able to decrease IRF3 and IRF7, and then activate NF-kappaB."

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Nickel(2+) inhibits IRF3. 2 / 2

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