IndraLab

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USP27X leads to the deubiquitination of AKT. 1 / 1
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reach
"Mechanistically, USP27X‐AS1 enhances USP7‐mediated deubiquitination and upgrading of AKT to promote HCC progression; we also showed that SP1 binds to the promoter of USP27X‐AS1, enhances USP27X‐AS1 transcription, revealing a novel regulatory axis of SP1‐USP27X‐AS1‐USP7‐AKT in HCC."