IndraLab

Statements

OTULIN activates inflammatory response. 7 / 7
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"To exclude the possibility that the effect of OTULIN on reducing microglia activation is an indirect outcome of its neuroprotective role [XREF_BIBR], a commonly used LPS induced pure brain inflammation model without brain cell death served as a positive control."
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"OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice."
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"Inactivation of OTULIN by expression of OTULIN C129A in adult mice has recently been reported to cause systemic inflammation, which can be prevented by combined ablation of cell death pathways by deletion of caspase-8, RIPK3 and RIPK1 (Heger etal, 2018)."
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"OTULIN deficiency triggers metabolic alterations, apoptosis, and inflammation in the liver."
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"Suppressing microglial activation and the expression of IL‐1β and TNFα significantly alleviates TN symptoms.Abnormal OTULIN function can lead to systemic inflammation in humans and mice."
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"These cellular and molecular mediators are indicative of an inappropriate and damaging inflammatory response mediated by OTULIN deficient myeloid cells."
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"Ablation of OTULIN in mice induces liver inflammation and fibrosis, leading to neoplastic lesions and liver cancer [52]."
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