IndraLab

Statements

OTULIN activates inflammatory response. 5 / 5
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"Inactivation of OTULIN by expression of OTULIN C129A in adult mice has recently been reported to cause systemic inflammation, which can be prevented by combined ablation of cell death pathways by deletion of caspase-8, RIPK3 and RIPK1 (Heger etal, 2018)."
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"To exclude the possibility that the effect of OTULIN on reducing microglia activation is an indirect outcome of its neuroprotective role [XREF_BIBR], a commonly used LPS induced pure brain inflammation model without brain cell death served as a positive control."
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"OTULIN deficiency triggers metabolic alterations, apoptosis, and inflammation in the liver."
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"These cellular and molecular mediators are indicative of an inappropriate and damaging inflammatory response mediated by OTULIN deficient myeloid cells."
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"OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice."
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