IndraLab

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Melatonin inhibits JUN. 3 / 3
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"Lastly, a combination of melatonin and mercaptopurine can be used to inhibit the c-jun signaling which is activated upon SARS-CoV-2 contributing to the pathogenesis of the disease as the signaling mediates the effect of several other host proteins known to interact with viral proteins."
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"As shown in Fig. 6d, mercaptopurine and melatonin may synergistically block c-Jun signaling by targeting multiple cellular targets."
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"Melatonin could inhibit the activation of c-Jun N-terminal protein kinase 1, JNK, the upstream cell death pathway kinase, through phosphorylation of pro-apoptotic Bax prior to its translocation to mitochondria for promoting mitochondria-dependent apoptosis [219], thus protecting cells from autophagic cell death triggered by the Bcl-2/Beclin1 pathway."
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