IndraLab

Statements

USP18 activates Carcinogenesis. 5 / 5
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"In conclusion, our findings demonstrate that elevated expression of USP18 in HNSC cells promotes tumorigenesis by regulating the PLK1-mTORC1 pathway."
39424095
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"USP18 was shown to promote lung tumorigenesis and affect fatty acid metabolism [13]."
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"The effect of ISGylation of specific protein targets in the tumour microenvironment will also be the focus of our further research.Previous studies have shown that increased USP18 expression promotes tumorigenesis by increasing stability of critical ISG15‐conjugated oncogenic proteins (Basters et al., 2017; Liu et al., 2020; Pinto‐Fernandez et al., 2021)."
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"A study has indicated that USP18 contributes to controlling carcinogenesis, as loss of USP18 function increases apoptosis and decreases cell proliferation by destabilization of the cyclin D1 protein 22.It remains, however, unclear so far whether the EFP, HERC5 and USP18 genes contribute to tumourigenesis through ISG15/ISGylation or other mechanisms."
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"By stabilizing KRAS, USP18 sustains KRAS signaling and promotes tumorigenesis by upregulating the growth regulator cyclin D1 [178]."
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