IndraLab

Statements

USP15 activates Parkinson Disease. 3 / 3
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"Therefore, the activities of USP30 and USP15 in antagonizing Parkin would be expected to promote PD phenotypes [62]."
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"Furthermore, USP15 KD was able to rescue the mitophagy defect of Parkin and PINK1 mutant PD patient fibroblasts."
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"Previous research has reported that ubiquitin-specific protease 15 (USP15) antagonizes parkin-mediated mitochondrial ubiquitination and that USP15 knockout can rescue mitophagy impairment in PD patient brains with PARK2 mutation [131]."
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