IndraLab

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USP8 deubiquitinates TGFBR. 4 / 4
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"In breast cancer, the type II TGF-β receptor TβRII is directly deubiquitinated and stabilized by USP8, which increases the expression of TβRII in the plasma membrane as well as tumor-derived extracellular vesicles (TEVs)."
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"USP8 promotes tumor progression and T cell depletion in breast cancer by deubiquitinating the TGF-β receptor, TβRII ."
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"USP8 also is capable of directly deubiquitinating and stabilizing the type II TGF-β receptor TβRII which expressed in cell membrane and tumor-derived extracellular vesicles (TEVs)."
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"Xie et al. proved that ubiquitin-specific peptidase 8 (USP8) enhanced BC metastasis by deubiquitinating and stabilizing the TGF-β receptor TβRII, thus leading to increased TGF-β/SMAD signaling (85)."
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