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USP1 activates PI3K. 5 / 5
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"They used a PI3K inhibitor (S2793) to reverse the effects of USP1 and found that USP1 overexpression activated the PI3K/AKT signaling pathway, causing tumor cell migration and invasion in HNSCC (92,99)."
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"Overall, these data suggest that USP1 was able to promote PI3K/AKT signaling ( Fig. 10 G)."
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"In summary, our study shows that expression of USP1 in nonunion patients and rats increases and inhibition of USP1 promotes the fracture healing by facilitating the expression of osteogenesis-related factors and the signaling of PI3K/Akt pathway in nonunion rats."
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"Furthermore, when NPC cells were treated with S2739 to inhibit the PI3K pathway, the effects of USP1 overexpression in NPC cells were reversed."
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"Western blot data showed that after USP1 cDNA transfection, PI3K/Akt-related proteins (PI3K, p-PI3K, Akt, p-Akt) were significantly increased, indicating that USP1 may activate the PI3K/Akt axis ( Fig[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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