IndraLab

Statements

OTUD7B deubiquitinates LEF1. 4 / 4
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"As shown in Figure 3, OTUD7B did not noticeably deubiquitinate LEF1, and its protein stability was not affected by OTUD7B."
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"Despite its interaction with LEF1 and enhancement of Wnt signaling activity, it was surprising that OTUD7B did not deubiquitinate LEF1 or affect its protein stability."
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"OTUD7B Does Not Deubiquitinate nor Stabilize LEF1."
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"Since LEF1 is targeted for proteasomal degradation through ubiquitination by multiple E3 ligases, including NARF and Pja2 [19,20], we investigated whether OTUD7B deubiquitinates LEF1 and regulates its protein stability."
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