IndraLab

Statements

USP15 activates CGAS. 5 / 5
| 3 2
sparser
"USP15 activates cGAS in the presence of DNA by two parallel pathways: facilitating cGAS deubiquitination and enhancing its phase separation, which contrasts with conventional cGAS deubiquitination mechanisms, such as those mediated by USP14 ( xref , xref )."
40028324
reach
"Ubiquitin-Specific-Processing Protease 15 (USP15), a protease involved in protein deubiquitination, promotes the cGAS–STING signaling through two independent mechanisms."
36839515
reach
"On the other hand, USP15, through its IDR region, can promote the condensate formation of cGAS [33]."
36839515
sparser
"In innate immunity, the cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING)pathway, a core DNA sensing mechanism, undergoes multi-level regulation by USP15 deubiquitination: USP15 activates cGAS via deubiquitination and feeds back positively to promote its dimerization and phase separation."
40642070
reach
"USP15 activates cGAS in the presence of DNA by two parallel pathways: facilitating cGAS deubiquitination and enhancing its phase separation, which contrasts with conventional cGAS deubiquitination mechanisms, such as those mediated by USP14 (18, 23)."
40028324