IndraLab

Statements

CTNNB1 phosphorylates CTNNB1 on S552. 5 / 5
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"PFKP Y64 Phosphorylation by EGFR Enhances AKT-Mediated beta-Catenin S552 Phosphorylation and Nuclear Translocation of beta-Catenin and Expression of Its Downstream Genes."
32195176
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"Taken together, our results suggest TNF activates beta-catenin through the AKT mediated phosphorylation of beta-catenin (Ser552) rather than via Wnt upregulation."
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"Macrophages from B6 and Akt1 −/− mice were stimulated for the indicated time points with poly(I:C) and total cell lysates were resolved by PAGE and probed for β-catenin as well as phosphorylated β-catenin at Ser552."
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"In the presence of Wnt, N-cadherin regulates LRP6 phosphorylation, while when Wnt is absent, N-cadherin also regulates beta-catenin transcriptional activation via AKT mediated phosphorylation of beta-catenin Ser 552."
23618343
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"Total beta-catenin, de-phosphorylated beta-catenin (canonical activation, de-phospho beta-catenin) and phosphorylated beta-catenin at Ser 552 (non canonical activation, p-Ser 552 beta-catenin) levels were determined in primary human dermal fibroblasts, cytosol and nucleus, by western blot analysis and fluorescence microscopy, before and after stimulation by A 2A receptor selective agonist CGS21680, with and without A 2A receptor selective antagonist (SCH56261) pretreatment."
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