IndraLab

Statements

Celastrol inhibits STAT1. 3 / 3
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"Previous studies have demonstrated that JNK is involved in poly (I : C)-induced STAT1 activation, and we found that celastrol suppressed poly (I : C)-induced activation of STAT1."
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"In addition, celastrol significantly suppressed poly (I : C)-induced activation of JNK MAPK and STAT1 signaling pathways."
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"Pre-loading celastrol for 30 min could inhibit the actions of MEK1, ERK1, NF-kappaB (p65), and STAT1, but not p38 (XREF_FIG)."
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