IndraLab

Statements

PXN inhibits KCNMA1. 4 / 4
| 4
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"To examine whether BK channels are activated during complex spike pauses, we bath applied the BK channel blocker paxillin (1microM), while apamin (10nM) was continuously present in the bath."
26972012
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"In preclinical studies, several non-selective BK channel-blocking substances, including iberiotoxin, paxillin, and charybdotoxin, were used, which were able to inhibit the physiological effects induced by CGRP and PACAP [3,40,66]."
38068897
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"To record Kv currents, freshly isolated SMCs were patch-clamped in the amphotericin B perforated configuration in the presence of the selective BK channel blocker paxillin (1 µM), and voltage-dependent currents were evoked by the application of a series of voltage steps from −60 to +60 mV from a holding potential of −80 mV."
36693102
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"Such a decrease in the number and amplitude of APs was also shown in dentate gyrus hippocampal neurons of epileptic rats during a 250 pA current injection, when the cells were treated with BK channel blockers paxillin and iberiotoxin."
| PMC