IndraLab

Statements

Propofol inhibits NLRP3. 9 / 9
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"Our present study also implied that propofol up-regulated Nrf2 and down-regulated NLRP3 in VILI model."
32199914
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"Propofol pretreatment also prevented the association of NLRP3, ASC and pro-caspase-1 in LPS injured cardiomyocytes."
33398367
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"The results indicated that propofol pretreatment suppressed the priming and activation of NLRP3 inflammasome in LPS injured cardiomyocytes."
33398367
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"Propofol Inhibits NLRP3 Inflammasome and Attenuates Blast Induced Traumatic Brain Injury in Rats."
27696022
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"Therefore, the results suggested that the potential beneficial effects of propofol against septic myocardial injury were dependent on PPARgamma activation to suppress HMGB1 dependent NLRP3 inflammasome activation."
33398367
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"However, this effect disappeared in mice with depleted microglia, indicating that NLRP3 inflammasome is involved in the inflammatory response to TBI, and MCC950’ s specific inhibition of NLRP3 inflammasome may be a promising therapeutic approach for TBI.In addition, JC124, HET0016, ACT001, pathenolide, mangiferin, propofol and other drugs have been reported to reduce the activation of NLRP3 inflammasome and caspase-1 around injury in TBI mice, and alleviate neurological deficits and neuronal damage [48–52]."
38849934
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"In the rat model, propofol reduced CFA-induced inflammatory pain and inhibited the inflammatory response by regulating the p38MAPK-NF-κB pathway and the NLRP3 inflammasome."
31889729
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"The results suggested that propofol pretreatment inactivated HMGB1 dependent NLRP3 inflammasome signaling, which involved PPARgamma activation."
33398367
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"Propofol significantly inhibits BK induced increase of NLRP3 inflammasome."
29940605