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Astemizole inhibits KCNH2-S631C. 3 / 3
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"Surprisingly, under oxidizing conditions, we found that HERG S631C currents, evoked by application of pulses to +20 mV with intervals of 8 s from a holding potential of -90 mV, could not be blocked by[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To investigate whether astemizole blocks HERG S631C channels, HERG S631C cRNA was expressed in oocytes and currents were investigated 2 days after injection."
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"Under these conditions, we found that HERG S631C currents, evoked by application of pulses to 0 mV with intervals of 8 s from a holding potential of -90 mV, could be completely blocked by 1 muM astemi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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