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USP18 deubiquitinates CGAS. 3 / 3
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"However, this idea needs further validation.In conclusion, our results suggest that USP18 deubiquitinates and stabilizes cGAS and activates cGAS-STING pathway, thereby mediating innate immune defense [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, immunoblotting showed that the knockdown of USP18 notably inhibited the decrease of cGAS ubiquitination and increased protein expression induced by vemurafenib ( Fig. 5 K)."
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"In the present study, our RT-qPCR combined with bioinformatics analysis revealed that USP18 could deubiquitinate cGAS to induce protective autophagy in BRAF V600E mutant melanoma."
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