IndraLab

Statements

Mutated ATXN3 inhibits PRKN. 4 / 4
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"Mutant Ataxin-3, a polyglutamine dilatation associated with the onset of Machado-Joseph neurodegenerative disease, promotes Parkin degradation by autophagy and leads to a decrease in Parkin levels in in vivo [40]."
31753025
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"Mutant ataxin-3 promotes the autophagic degradation of parkin."
21116127
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"Mutation of ataxin 3 accelerates the degradation of parkin by autophagy ( Durcan and Fon, 2011 )."
34023421
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"For example, mutant ataxin-3, the causative protein abnormality in SCA3, has been shown to enhance the autophagic degradation of parkin, which may in turn explain some of the parkinsonian features seen in this condition [XREF_BIBR]."
24307138